Rosenkranz H S, Winshell E B, Mednis A, Carr H S, Ellner C J
J Bacteriol. 1967 Oct;94(4):1025-33. doi: 10.1128/jb.94.4.1025-1033.1967.
Hydroxyurea affected neither the synthesis nor the degradation of bacterial messenger-ribonucleic acid. The proteins made by hydroxyurea-treated cells were structurally intact and fully functional. Since the expression of the lethal action of hydroxyurea requires active protein production, the data indicate that treated cells do not die as the result of the synthesis of abnormal proteins.
羟基脲既不影响细菌信使核糖核酸的合成，也不影响其降解。经羟基脲处理的细胞所产生的蛋白质在结构上完整且功能齐全。由于羟基脲致死作用的表达需要活跃的蛋白质合成，这些数据表明，经处理的细胞并非因合成异常蛋白质而死亡。
