羟基脲的研究。II. 大肠杆菌长时间暴露于羟基脲。
Studies with hydroxyurea. II. Prolonged exposure of Escherichia coli to hydroxyurea.
作者信息
Rosenkranz H S, Carr H S
出版信息
J Bacteriol. 1966 Jul;92(1):178-85. doi: 10.1128/jb.92.1.178-185.1966.
Abstract
Rosenkranz, Herbert S. (Columbia University, New York, N.Y.), and Howard S. Carr. Studies with hydroxyurea. II. Prolonged exposure of Escherichia coli to hydroxyurea. J. Bacteriol. 92:178-185. 1966.-Concurrent with an inhibition of the synthesis of deoxyribonucleic acid, hydroxyurea devitalized Escherichia coli when exposure to the drug was prolonged to more than 3 hr. Active protein synthesis, but not ribonucleic acid (RNA) production, was a prerequisite for this lethal action. These findings are contrasted to thymineless death, which requires RNA synthesis.
摘要
罗森克兰茨，赫伯特·S.（纽约哥伦比亚大学），以及霍华德·S.卡尔。羟基脲研究。II. 大肠杆菌长时间暴露于羟基脲。《细菌学杂志》92:178 - 185。1966年。——在抑制脱氧核糖核酸合成的同时，当大肠杆菌暴露于羟基脲的时间延长至超过3小时时，羟基脲会使其失去活力。活跃的蛋白质合成而非核糖核酸（RNA）的产生是这种致死作用的前提条件。这些发现与无胸腺死亡形成对比，无胸腺死亡需要RNA合成。
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