苯丙胺衍生物对脑多巴胺和去甲肾上腺素的影响。
Effects of amphetamine derivatives on brain dopamine and noradrenaline.
作者信息
Breese G R, Kopin I J, Weise V K
出版信息
Br J Pharmacol. 1970 May;38(3):537-45. doi: 10.1111/j.1476-5381.1970.tb10595.x.
Abstract
- Intracisternally administered metaraminol, alpha-methyl-octopamine, alpha-methyl-m-tyramine, and alpha-methyl tyramine were found to lower brain noradrenaline without having an effect on brain dopamine.2. Amphetamine, mephentermine, and norephedrine had no effect on brain catecholamines after intracisternal injection.3. There was no reduction in brain dopamine content after intracisternal injection of alpha-methyl-m-tyramine, yet the resulting brain concentration of alpha-methyl-m-tyramine was several times higher than after intraperitoneal injection of alpha-methyl-m-tyrosine, which decreased brain dopamine.4. The decreased synthesis of labelled catecholamines from (14)C-tyrosine after alpha-methyl-m-tyrosine suggested that this compound inhibits tyrosine hydroxylase in addition to its action of displacing brain amines.
摘要
发现脑池内注射间羟胺、α-甲基去甲辛福林、α-甲基间酪氨酸和α-甲基酪氨酸可降低脑内去甲肾上腺素水平，而对脑内多巴胺无影响。
脑池内注射苯丙胺、美芬丁胺和去甲麻黄碱后，对脑内儿茶酚胺无影响。
脑池内注射α-甲基间酪氨酸后，脑内多巴胺含量未降低，但由此产生的脑内α-甲基间酪氨酸浓度比腹腔注射降低脑内多巴胺的α-甲基酪氨酸后高出数倍。
α-甲基酪氨酸注射后，由（14）C-酪氨酸合成标记儿茶酚胺的过程减少，这表明该化合物除了具有取代脑内胺类的作用外，还抑制酪氨酸羟化酶。
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