大肠杆菌中分解代谢酶瞬时抑制的生理基础。
Physiological basis of transient repression of catabolic enzymes in Escherichia coli.
作者信息
Tyler B, Magasanik B
出版信息
J Bacteriol. 1970 May;102(2):411-22. doi: 10.1128/jb.102.2.411-422.1970.
Abstract
Transient repression of catabolic enzymes occurs in cells that encounter a new carbon compound in their growth medium, but only when the cells contain the enzyme catalyzing the transfer of phosphate from phosphoenolpyruvate to a small heat-stable protein (HPr), as well as a permease capable of transporting the new compound across the cell membrane. The newly added compound need not be metabolized. The degree and duration of the transient repression have no obvious relation to the intracellular level of the exogenously added compound. It is suggested that the actual passage of the compound through the cell membrane is responsible for the repression.
摘要
在生长培养基中遇到新碳化合物的细胞中会发生分解代谢酶的短暂抑制，但前提是细胞含有催化磷酸从磷酸烯醇丙酮酸转移至一种小的热稳定蛋白（HPr）的酶，以及一种能够将新化合物转运穿过细胞膜的通透酶。新添加的化合物无需被代谢。短暂抑制的程度和持续时间与外源添加化合物的细胞内水平无明显关系。据推测，化合物实际穿过细胞膜是导致这种抑制的原因。
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