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[在冠状动脉血流测量受限情况下心肌能量过程的指标]

[Indices of the energy processes in the myocardium in measured limitation of the coronary blood flow].

作者信息

Frol'kis R A

出版信息

Kardiologiia. 1979 Sep;19(9):103-7.

PMID:491368
Abstract

Oxidative phosphorylation, the content of creatine phosphate and inorganic phosphorus and the activity of some mitochondrial respiratory enzymes, creatine phosphokinase and Mg-dependent ATP-ase were studied in experiments on 54 dogs with dosed restriction of coronary blood flow in different parts of the heart. It was established that restriction of coronary blood flow in the circumflex branch of the left coronary artery by 30 and and 50% for 30 minutes is attended by a mild decrease in the intensity of oxidative processes, the level of creatine phosphate and cytochrome oxidase activity. The right cardiac ventricle reacts to short-term and partial decrease in coronary blood flow; all stages of energy metabolism are activated here.

摘要

在54只犬身上进行实验,对心脏不同部位的冠状动脉血流进行定量限制,研究了氧化磷酸化、磷酸肌酸和无机磷含量以及一些线粒体呼吸酶、肌酸磷酸激酶和镁依赖性ATP酶的活性。结果表明,左冠状动脉回旋支的冠状动脉血流分别限制30%和50%持续30分钟时,氧化过程强度、磷酸肌酸水平和细胞色素氧化酶活性轻度降低。右心室对冠状动脉血流的短期和部分减少有反应,此处能量代谢的各个阶段均被激活。

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