[Creatine and phosphocreatine concentrations and creatine phosphokinase activity in the hearts of dogs with restricted coronary blood flow].

Alterations in some patterns of energy metabolism, which are essential for energy transport in myocardial cells, were studied in dogs with local artificial impairment by 70% of coronary circulation. In this case activity of creatine phosphokinase and content of creatine phosphate were decreased, particularly in the ischemic zone, but creatine concentration was unaltered. Possible role of creatine is discussed not only as a regulator of systolic pressure but also as an indicator of the functional state of myocardium.