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[冠状动脉血流实验性紊乱时心肌中肌酸激酶系统的组成部分]

[Components of the creatine kinase system in the myocardium with experimental disturbance of coronary blood flow].

作者信息

Voronkov G S

出版信息

Ukr Biokhim Zh (1978). 1982 Mar-Apr;54(2):167-70.

PMID:7080219
Abstract

Certain key parameters of energy metabolism in a complex mechanism of energy transport in the myocardium cells were studied in experiments on dogs with dosed limitation of the coronary blood flow (by 90%) as well as in experiments on rabbits with the intravenous injection of vasopressin (0.2 units per 1 kg of mass). Animals of all groups under study revealed essential changes in the content of creatine phosphate and in the activity of creatine phosphokinase as compared with the control groups. A possible role of creatine phosphokinase is discussed in the processes of myocardium function energy supply under conditions of creatine phosphate deficiency during a slightly pronounced ischemia.

摘要

在对冠状动脉血流进行定量限制(减少90%)的犬类实验以及静脉注射血管加压素(每千克体重0.2单位)的兔类实验中,研究了心肌细胞能量转运复杂机制中能量代谢的某些关键参数。与对照组相比,所有研究组的动物在磷酸肌酸含量和磷酸肌酸激酶活性方面均出现了显著变化。本文讨论了在轻度缺血期间磷酸肌酸缺乏的情况下,磷酸肌酸激酶在心肌功能能量供应过程中的可能作用。

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