Shain S A, Nitchuk W M
Mech Ageing Dev. 1979 Aug;11(1):9-22. doi: 10.1016/0047-6374(79)90060-5.
Testosterone metabolism by the ventral prostate of inbred, senescent (36-month-old) AXC rats showed a shift to increased oxidative and diminished reductive metabolism when compared to young mature (3-month-old) or mature adult (6-month-old) AXC rats. The change was principally attributable to diminished production of 5 alpha-dihydrotestosterone and increased production of 4-androstenedione. By contrast, dorsolateral prostate testosterone metabolism in these same rats was always more reductive than that of ventral prostate and failed to show the post-maturation shift to oxidative testosterone metabolism which characterized ventral prostate. Co-incubation of either ventral or dorsolateral prostate from any of these rats with testosterone and estradiol showed that estradiol did not significantly affect prostate testosterone metabolism. Plasma testosterone content of senescent AXC rats was only 28% of that of mature adult rats. Chronic exogenous testosterone treatment enhanced reductive testosterone metabolism by ventral prostate and eliminated those changes in metabolite distribution which had differentiated testosterone metabolism by young and senescent AXC rats. The data support the interpretation that the aging-related diminution in AXC rat ventral prostate reductive metabolic capacity is primarily the consequence of diminished 5 alpha-dihydrotestosterone production secondary to diminished plasma testosterone content.
与年轻成熟（3个月大）或成熟成年（6个月大）的AXC大鼠相比，近交系衰老（36个月大）AXC大鼠腹侧前列腺的睾酮代谢显示出向氧化代谢增加和还原代谢减少的转变。这种变化主要归因于5α-双氢睾酮产量的减少和4-雄烯二酮产量的增加。相比之下，这些相同大鼠的背外侧前列腺睾酮代谢总是比腹侧前列腺更具还原性，并且没有表现出成熟后向以腹侧前列腺为特征的氧化睾酮代谢的转变。将这些大鼠中任何一只的腹侧或背外侧前列腺与睾酮和雌二醇共同孵育表明，雌二醇对前列腺睾酮代谢没有显著影响。衰老AXC大鼠的血浆睾酮含量仅为成熟成年大鼠的28%。慢性外源性睾酮治疗增强了腹侧前列腺的还原性睾酮代谢，并消除了那些区分年轻和衰老AXC大鼠睾酮代谢的代谢物分布变化。这些数据支持这样的解释，即AXC大鼠腹侧前列腺还原代谢能力与衰老相关的降低主要是血浆睾酮含量降低导致5α-双氢睾酮产量减少的结果。
