Yocum M W, Grossman J, Waterhouse C, Abraham G N, May A G, Condemi J J
Arthritis Rheum. 1975 May-Jun;18(3):193-9. doi: 10.1002/art.1780180301.
A pair of monozygotic twins discordant for systemic lupus erythematosus(SLE) were studied and no differences noted in their immune respose to tetanus toxoid, keyhole lympet hemocyanin, DNCB, delayed sensitivity, or antibody titers to viruses. Both were noted to have biologically false positive serology at an early age, but only one twon developed SLE. The clinically unaffected twin underwent castration at an early age, suggesting that ovarian hormones may play an important role in the development of SLE.
对一对患系统性红斑狼疮（SLE）的单卵双胞胎进行了研究，发现他们对破伤风类毒素、钥孔戚血蓝蛋白、二硝基氯苯、迟发型超敏反应或病毒抗体滴度的免疫反应没有差异。两人在幼年时均出现生物学假阳性血清学现象，但只有其中一个双胞胎患了SLE。临床上未受影响的双胞胎在幼年时接受了阉割，这表明卵巢激素可能在SLE的发病中起重要作用。
