骨髓细胞对C57BL - 6小鼠化学诱导淋巴瘤影响的进一步研究。
Further studies of the effect of bone marrow cells on chemically induced lymphoma in C57BL-6 mice.
作者信息
Chen L
出版信息
Br J Cancer. 1970 Sep;24(3):554-60. doi: 10.1038/bjc.1970.67.
Injection of syngeneic bone marrow cell to adult C57BL/6 mice treated DMBA intragastrically failed to prevent lymphoma induced by the chemical.The present result seem to indicate that bone marrow cells do not hasten the regeneration of the transient injuried thymus by DMBA as compared with their effect in irradiated mice.IT APPEARS THAT, UNDER THE CONDITIONS USED, DMBA DOES NOT CAUSE SIGNIFICANT DAMAGE TO THE BONE MARROW SINCE MARROW CELLS FROM CHEMICALLY TREATED MICE WERE AS EFFECTIVE AS NORMAL MARROW CELLS IN: (a) preventing radiogenic leukaemia, (b) repairing radiation damage of the thymus, (c) preventing the lethal action of high doses of irradiation.Marrow cells failed to restore antibody formation to Shigella depressed by DMBA as they do in irradiated mice.The result strengthen our previous view on the critical role of bone marrow on the effects caused by irradiation and not in the leukaemia process as such.
向经胃内给予二甲基苯蒽（DMBA）处理的成年C57BL/6小鼠注射同基因骨髓细胞，未能预防该化学物质诱导的淋巴瘤。目前的结果似乎表明，与骨髓细胞对受照射小鼠的作用相比，其对DMBA所致短暂损伤的胸腺再生并无促进作用。在所用条件下，DMBA似乎不会对骨髓造成显著损伤，因为来自经化学处理小鼠的骨髓细胞在以下方面与正常骨髓细胞同样有效：（a）预防辐射诱发的白血病；（b）修复胸腺的辐射损伤；（c）预防高剂量辐射的致死作用。骨髓细胞未能像在受照射小鼠中那样，恢复被DMBA抑制的针对志贺氏菌的抗体形成。这些结果强化了我们之前关于骨髓在辐射所致效应而非白血病进程本身中起关键作用的观点。
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