大鼠子宫肌层电生性钠泵的特性
Characteristics of electrogenic sodium pumping in rat myometrium.
作者信息
Taylor G S, Paton D M, Daniel E E
出版信息
J Gen Physiol. 1970 Sep;56(3):360-75. doi: 10.1085/jgp.56.3.360.
Abstract
Sodium-rich myometrium, obtained from the uteri of pregnant rats, rapidly hyperpolarized when 4.6-120 mM potassium was added to the bathing medium at 37 degrees C. Hyperpolarization was due to sodium pumping since the process was markedly temperature dependent, was abolished by ouabain, and required both intracellular sodium and extracellular potassium. The observed membrane potential exceeded the calculated potassium equilibrium potential during hyperpolarization providing evidence that sodium pumping was electrogenic. Hyperpolarization was reduced in the presence of chloride. The rate of sodium pumping may influence potassium permeability since potassium apparently did not short-circuit the pump during hyperpolarization.
摘要
从妊娠大鼠子宫获取的富含钠的子宫肌层，当在37℃下向浴液中添加4.6 - 120 mM钾时，会迅速发生超极化。超极化是由于钠泵作用，因为该过程明显依赖温度，被哇巴因消除，且需要细胞内钠和细胞外钾。在超极化期间观察到的膜电位超过计算出的钾平衡电位，这表明钠泵作用是生电的。在有氯离子存在的情况下，超极化程度降低。钠泵作用速率可能会影响钾通透性，因为在超极化过程中钾显然没有使泵短路。
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