Koppenhagen K, Wenig H G
Med Klin. 1979 Aug 31;74(35):1254-6.
Using 198Au-colloid scintigraphy (Anger camera computer-system, 0.3-0.5 mCi radionuclide i.v.) the pattern of liver blood flow, i.e. liver perfusion volume per minute (LPVM), was monitored in 7 patients with liver metastasis (I), 8 patients each with chronic hepatitis (II) and liver cirrhosis (III) and in 10 healthy control subjects (IV). Reading were compared on a within patient basis for the following treatments: baseline control, after a single i.v. injection of 10 ml Trental (= 200 mg pentoxifylline) and after 10 ml physiological saline solution (= placebo). The alteration of LPVM ranged between +0.6 and -3.2% for the comparison baseline/placebo, between +9.7 and +40.8% for baseline/Trental and between +11.5 and +45.4% for placebo/Trental administration. The increase of the elimination constant was statistically significant for all groups and the augmentation of the LPVM for group II, III and IV.
使用198金胶体闪烁扫描法（安格相机计算机系统，静脉注射0.3 - 0.5毫居里放射性核素），对7例肝转移患者（I组）、8例慢性肝炎患者（II组）和8例肝硬化患者（III组）以及10名健康对照者（IV组）的肝脏血流模式，即每分钟肝脏灌注量（LPVM）进行了监测。在患者自身基础上，对以下治疗后的读数进行了比较：基线对照、静脉单次注射10毫升曲克芦丁（= 200毫克己酮可可碱）后以及静脉注射10毫升生理盐水溶液（= 安慰剂）后。基线/安慰剂比较时，LPVM的变化范围在+0.6%至 - 3.2%之间；基线/曲克芦丁比较时，变化范围在+9.7%至 + 40.8%之间；安慰剂/曲克芦丁给药比较时，变化范围在+11.5%至 + 45.4%之间。所有组消除常数的增加具有统计学意义，II组、III组和IV组的LPVM增加也具有统计学意义。
