Koppenhagen K
Pharmatherapeutica. 1984;4(1):1-5.
A single-blind, crossover study was carried out in 9 healthy subjects to investigate the effect of a single dose of 2 tablets of 400 mg pentoxifylline ('Trental' 400) or placebo on cerebral blood flow, cerebral perfusion quotient and mental functions under experimental hypobaric conditions. Subjects were exposed in a low pressure chamber to simulated atmospheric pressures at sea level, 4000 and 7000 metres, and tests were performed 2 hours after intake of the dose, using 99m technetium brain scintigraphy and psychometric tests, to assess acutely induced impairment of cerebral function. After placebo, cerebral blood flow was decreased, especially at the 7000 metre level, whereas there was significantly less decrease after pentoxifylline. The perfusion quotient was normal throughout the pentoxifylline period but was outside the normal range in 8 of the 9 subjects after placebo. Psychometric testing showed better performance by the subjects after drug than after placebo intake. The results suggest that pentoxifylline may protect cerebral blood flow, nutrition and function under impaired supply conditions.
对9名健康受试者进行了一项单盲交叉研究，以调查在实验性低压条件下，单次服用2片400毫克己酮可可碱（“曲克芦丁”400）或安慰剂对脑血流量、脑灌注商和心理功能的影响。受试者在低压舱中暴露于海平面、4000米和7000米的模拟大气压力下，并在服用药物2小时后进行测试，使用99m锝脑闪烁扫描和心理测试，以评估急性诱导的脑功能损害。服用安慰剂后，脑血流量减少，尤其是在7000米水平，而服用己酮可可碱后减少明显较少。在整个己酮可可碱治疗期间，灌注商正常，但服用安慰剂后，9名受试者中有8人的灌注商超出正常范围。心理测试表明，受试者服药后比服用安慰剂后的表现更好。结果表明，己酮可可碱可能在供应受损的情况下保护脑血流量、营养和功能。
