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小鼠补体对大肠杆菌的体内杀菌活性。

In vivo bactericidal activity of mouse complement against Escherichia coli.

作者信息

Medhurst F A, Glynn A A

出版信息

Br J Exp Pathol. 1970 Oct;51(5):498-506.

PMID:4923650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2072216/
Abstract

Live of complement sensitive and resistant strains were labelled with C and injected i.v. into normal mice and into a co-isogenic strain deficient in C′5. The fate of the bacteria was followed by determining total and viable counts in blood samples taken at intervals over a 30 min. period and in homogenates of the liver, spleen, lungs and kidneys taken at the end of the experiment. The results show that sensitive bacteria can be killed by mouse complement within the circulation and suggest that complement may also play a part in the intracellular killing of in some organs.

摘要

对补体敏感和有抗性的菌株进行活体细胞标记，然后静脉注射到正常小鼠和同基因C′5缺陷菌株体内。通过测定在30分钟内每隔一段时间采集的血样中的细菌总数和活菌数，以及在实验结束时采集的肝脏、脾脏、肺和肾脏匀浆中的细菌总数和活菌数，来追踪细菌的命运。结果表明，敏感细菌可被小鼠补体在循环系统中杀死，这表明补体在某些器官内对细菌的细胞内杀伤中可能也起作用。

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本文引用的文献

1
Presence of complement in serum of the mouse.小鼠血清中补体的存在。
Proc Soc Exp Biol Med. 1952 Jul;80(3):419-20. doi: 10.3181/00379727-80-19642.
2
The repression of constitutive beta-galactosidase in Escherichia coli by glucose and other carbon sources.葡萄糖及其他碳源对大肠杆菌中组成型β-半乳糖苷酶的抑制作用。
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STUDIES ON PHAGOCYTOSIS OF BACTERIA BY THE RETICULOENDOTHELIAL SYSTEM IN A STRAIN OF MICE LACKING HEMOLYTIC COMPLEMENT.缺乏溶血补体的小鼠品系中网状内皮系统对细菌吞噬作用的研究。
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Activity of mouse complement.小鼠补体的活性
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Changes produced in mouse plasma proteins by acute bacterial infections.急性细菌感染对小鼠血浆蛋白产生的变化。
J Exp Med. 1961 Sep 1;114(3):311-25. doi: 10.1084/jem.114.3.311.
6
[Quantitative study of the granulopectic activity of the reticuloendothelial system of mice].[小鼠网状内皮系统粒细胞吞噬活性的定量研究]
C R Seances Soc Biol Fil. 1954 Mar;148(5-6):431-5.
7
Lack of bactericidal effect of mouse serum on a number of common microorganisms.小鼠血清对多种常见微生物缺乏杀菌作用。
Science. 1954 Jun 18;119(3103):877. doi: 10.1126/science.119.3103.877.
8
The high-resolution mass spectra of bisbenzyltetrahydroisoquinoline alkaloids. The structure of hayatin.双苄基四氢异喹啉生物碱的高分辨率质谱。海牙亭的结构。
J Chem Soc Perkin 1. 1966;21:1966-8. doi: 10.1039/j39660001966.
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Sites of synthesis of serum proteins. OI. Serum proteins produced by macrophages in vitro.血清蛋白的合成部位。OI。巨噬细胞在体外产生的血清蛋白。
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