Medhurst F A, Glynn A A
Br J Exp Pathol. 1970 Oct;51(5):498-506.
Live of complement sensitive and resistant strains were labelled with C and injected i.v. into normal mice and into a co-isogenic strain deficient in C′5. The fate of the bacteria was followed by determining total and viable counts in blood samples taken at intervals over a 30 min. period and in homogenates of the liver, spleen, lungs and kidneys taken at the end of the experiment. The results show that sensitive bacteria can be killed by mouse complement within the circulation and suggest that complement may also play a part in the intracellular killing of in some organs.
对补体敏感和有抗性的菌株进行活体细胞标记，然后静脉注射到正常小鼠和同基因C′5缺陷菌株体内。通过测定在30分钟内每隔一段时间采集的血样中的细菌总数和活菌数，以及在实验结束时采集的肝脏、脾脏、肺和肾脏匀浆中的细菌总数和活菌数，来追踪细菌的命运。结果表明，敏感细菌可被小鼠补体在循环系统中杀死，这表明补体在某些器官内对细菌的细胞内杀伤中可能也起作用。
