阿米替林在全科医疗中的对照试验。
Controlled trial of amitriptyline in general practice.
作者信息
Blashki T G, Mowbray R, Davies B
出版信息
Br Med J. 1971 Jan 16;1(5741):133-8. doi: 10.1136/bmj.1.5741.133.
Abstract
A controlled double-blind trial of amitriptyline at two dosage levels (75 and 150 mg/day), amylobarbitone (150 mg/day), and an inert substance for a period of four weeks was conducted on four matched groups of women attending their general practitioners and suffering from a depressive illness. Improvement at 7 and 28 days was noted on several measures of depression and anxiety in all treatment groups. Of these treatments amitriptyline 150 mg/day was the most consistent in relieving depression and anxiety. Troublesome side effects were equally distributed among the four treatments.
摘要
对四组匹配的、因患有抑郁症而就诊于全科医生的女性进行了一项对照双盲试验，试验为期四周，涉及两种剂量水平（75毫克/天和150毫克/天）的阿米替林、戊巴比妥（150毫克/天）以及一种惰性物质。在所有治疗组中，第7天和第28天时，多项抑郁和焦虑指标均显示有所改善。在这些治疗方法中，150毫克/天的阿米替林在缓解抑郁和焦虑方面最为稳定。令人烦恼的副作用在四种治疗方法中分布相同。
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