Greaves M W, Burton J L, Marks J, Dawber R P
Br Med J. 1971 Jan 16;1(5741):144-5. doi: 10.1136/bmj.1.5741.144.
Azathioprine was given to 11 patients with pemphigoid who had been on long-term maintenance therapy with prednisone or prednisolone. In nine of these prednisone therapy was withdrawn and all were maintained symptom-free on azathioprine alone, while in two the dose of prednisone was considerably reduced. One patient who had never received corticosteroids was controlled by azathioprine alone during the initial acute phase of the illness. Since azathioprine acts slowly, it is recommended that corticosteroids should be used together with azathioprine during the acute stage. Thus azathioprine is valuable in long-term management of pemphigoid, particularly in patients showing corticosteroid toxicity or in whom the minimum maintenance dose is dangerously high.
对11例类天疱疮患者给予硫唑嘌呤治疗，这些患者此前一直在接受泼尼松或泼尼松龙的长期维持治疗。其中9例停用了泼尼松治疗，所有患者仅使用硫唑嘌呤维持且无症状，另外2例患者泼尼松剂量大幅减少。1例从未接受过皮质类固醇治疗的患者在疾病初始急性期仅用硫唑嘌呤就得到了控制。由于硫唑嘌呤起效缓慢，建议在急性期将皮质类固醇与硫唑嘌呤联合使用。因此，硫唑嘌呤在类天疱疮的长期治疗中具有重要价值，尤其适用于出现皮质类固醇毒性或最低维持剂量高得危险的患者。
