硫唑嘌呤加泼尼松治疗类天疱疮。
Azathioprine plus prednisone in treatment of pemphigoid.
作者信息
Burton J L, Harman R R, Peachey R D, Warin R P
出版信息
Br Med J. 1978 Oct 28;2(6146):1190-1. doi: 10.1136/bmj.2.6146.1190.
Abstract
Twenty-five patients taking part in a controlled trial to compare azathioprine plus prednisone with prednisone alone in the treatment of pemphigoid were followed up for three years. Results showed that the addition of azathioprine 2.5 mg/kg body weight daily reduced the total maintenance dose of prednisone needed by about 45%, with no increase in serious side effects or mortality. The suggestion that azathioprine might increase the risk of disseminated malignancy in elderly patients was not supported. We conclude that in future trials the combination of azathioprine with prednisone should be used as the standard treatment for comparison.
摘要
25名参与一项对照试验的患者接受了为期三年的随访，该试验旨在比较硫唑嘌呤加泼尼松与单用泼尼松治疗类天疱疮的效果。结果显示，每日添加2.5mg/kg体重的硫唑嘌呤可使所需泼尼松的总维持剂量降低约45%，且严重副作用或死亡率并未增加。关于硫唑嘌呤可能增加老年患者播散性恶性肿瘤风险的说法未得到证实。我们得出结论，在未来的试验中，硫唑嘌呤与泼尼松联合应用应作为标准治疗方案用于比较。
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