Gerber N L, Steinberg A D
Drugs. 1976;11(1):14-35. doi: 10.2165/00003495-197611010-00002.
While immunosuppressive drugs are principally used in the treatment of malignant disease, their use in non-malignant disease and transplantation has become commonplace. The mechanisms of action of immunosuppressive agents differ. Alkylating agents react with nucleophilic centres of D, and rna. Folic acid antagonists prevnt the conversion of dihydrofolic acid to tetrahydrofolic acid. Antibiotics act in a variety of different ways; the alkaloids cause metaphase arrest. Cytarabine (cytosine arabinoside), methotrexate, hydroxyurea and thioguanine act during mitosis and the latter also acts during replication is not known...
虽然免疫抑制药物主要用于治疗恶性疾病，但它们在非恶性疾病和移植中的应用已变得很普遍。免疫抑制剂的作用机制各不相同。烷化剂与DNA和RNA的亲核中心发生反应。叶酸拮抗剂可阻止二氢叶酸转化为四氢叶酸。抗生素以多种不同方式起作用；生物碱会导致中期停滞。阿糖胞苷（胞嘧啶阿拉伯糖苷）、甲氨蝶呤、羟基脲和硫鸟嘌呤在有丝分裂期间起作用，而后者在复制期间的作用尚不清楚……
