Kobayashi K, Takahashi K
Neuroendocrinology. 1979;29(3):207-14. doi: 10.1159/000122924.
An abolishment of 24 h periodicity of the adrenocortical activity was observed in rats subjected to a prolonged food deprivation of 7--8 days. Total locomotor activity progressively decreased and its circadian rhythm faded out in a similar fashion as the adrenocortical rhythm. The circadian rhythms of both locomotor and adrenocortical activities were recovered after the rats were blinded and allowed free access to food. At the end of the first week, a peak elevation of blood corticosterone levels took place at the time corresponding to the light-dark transition before blinding. Similar patterns of locomotor activity and food intake were also noticed. The recovered rhythm of these activities free-run throughout the observation period of 5 weeks. This fact indicates that the endogenous time-keeping system (clock) remained intact and synchronized with light-dark alternation during the period of prolonged food deprivation.
在经历了7 - 8天长期食物剥夺的大鼠中，观察到肾上腺皮质活动的24小时周期性消失。总的运动活动逐渐减少，其昼夜节律与肾上腺皮质节律以相似的方式逐渐消失。在大鼠失明并能自由进食后，运动和肾上腺皮质活动的昼夜节律得以恢复。在第一周结束时，血液中皮质酮水平在与失明前的明暗转换相对应的时间出现峰值升高。还注意到了类似的运动活动和食物摄入模式。这些活动恢复的节律在5周的观察期内持续自由运行。这一事实表明，在长期食物剥夺期间，内源性计时系统（生物钟）保持完整并与明暗交替同步。
