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甘草干姜汤对BALB/c AnNCrl小鼠活动型厌食症的治疗作用

Therapeutic Effects of Licorice and Dried Ginger Decoction on Activity-Based Anorexia in BALB/c AnNCrl Mice.

作者信息

Kim Do-Hyun, Kim Joong Sun, Kim Jeongsang, Jeong Jong-Kil, Son Hong-Seok, Park Seong-Eun, Jo Jeakwon, Ryu Seung Mok, Kim Eun-San, Lee Sung-Jun, Lee Soong-In

机构信息

Department of Oriental Medicine, College of Oriental Medicine, Dongshin University, Naju, South Korea.

Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju, South Korea.

出版信息

Front Pharmacol. 2020 Dec 8;11:594706. doi: 10.3389/fphar.2020.594706. eCollection 2020.

DOI:10.3389/fphar.2020.594706
PMID:33519458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7845735/
Abstract

Licorice and dried ginger decoction (Gancao-ganjiang-tang, LGD) is used for nausea and anorexia, accompanied by excessive sweating in Traditional Chinese Medicine. Herein, we investigated the therapeutic effects of LGD using the activity-based anorexia (ABA) in a mouse model. Six-week-old female BALB/c AnNCrl mice were orally administered LGD, water, licorice decoction, dried ginger decoction, or chronic olanzapine, and their survival, body weight, food intake, and wheel activity were compared in ABA. Additionally, dopamine concentration in brain tissues was evaluated. LGD significantly reduced the number of ABA mice reaching the drop-out criterion of fatal body weight loss. However, LGD showed no significant effects on food intake and wheel activity. We found that in the LGD group the rise of the light phase activity rate inhibited body weight loss. Licorice or dried ginger alone did not improve survival rates, they only showed longer survival periods than chronic olanzapine when combined. In addition, LGD increased the dopamine concentration in the brain. The results from the present study showed that LGD improves the survival of ABA mice and its mechanism of action might be related to the alteration of dopamine concentration in the brain.

摘要

甘草干姜汤（甘草-干姜汤，LGD）在中医中用于治疗恶心、厌食，并伴有多汗。在此，我们在小鼠模型中利用基于活动的厌食症（ABA）研究了LGD的治疗效果。将六周龄雌性BALB/c AnNCrl小鼠口服给予LGD、水、甘草汤、干姜汤或慢性奥氮平，并在ABA模型中比较它们的存活率、体重、食物摄入量和转轮活动。此外，还评估了脑组织中的多巴胺浓度。LGD显著减少了达到致命体重减轻退出标准的ABA小鼠数量。然而，LGD对食物摄入量和转轮活动没有显著影响。我们发现，在LGD组中，光期活动率的升高抑制了体重减轻。单独使用甘草或干姜并不能提高存活率，它们仅在联合使用时显示出比慢性奥氮平更长的生存期。此外，LGD增加了脑中的多巴胺浓度。本研究结果表明，LGD可提高ABA小鼠的存活率，其作用机制可能与脑中多巴胺浓度的改变有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/354ef85e231b/fphar-11-594706-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/e53d793cc9ca/fphar-11-594706-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/3b988cdc48ca/fphar-11-594706-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/8407813aa0de/fphar-11-594706-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/1c32db59993a/fphar-11-594706-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/e9eacd4e8e9f/fphar-11-594706-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/354ef85e231b/fphar-11-594706-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/e53d793cc9ca/fphar-11-594706-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/3b988cdc48ca/fphar-11-594706-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/8407813aa0de/fphar-11-594706-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/1c32db59993a/fphar-11-594706-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/e9eacd4e8e9f/fphar-11-594706-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03e7/7845735/354ef85e231b/fphar-11-594706-g006.jpg

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