Takahashi K, Inoue K, Kobayashi K, Hayafuji C, Nakamura Y, Takahashi Y
Am J Physiol. 1978 May;234(5):E505-20. doi: 10.1152/ajpendo.1978.234.5.E515.
The possibility of a mutual influence between male adult rats having different circadian adrenocortical rhythms was studied under two different lighting conditions. Intact and optic-enucleated rats were housed together in the same cage in various ratios of intact to blinded rats. Twenty-four- or forty-eight-hour patterns of plasma corticosterone levels were determined individually at 4-h intervals. Under diurnal light-dark alternation, the circadian periodicity of the intact rats always synchronized with light, whereas single blinded rats in cages with three intact rats demonstrated free-running rhythms throughout the experimental period of 15 wk. Under constant light the circadian rhythm free-ran in both intact and blinded rats for the first 2 wk. A phase reversal of the rhythm was observed in the intact rats at the end of the 2nd wk, and between 5 and 8 wk after binding in the blinded rats. These results indicate that the circadian adrenocortical rhythms in intact and blinded rats are not entrained to each other, even when the two types of rats live together in the same cage.
在两种不同光照条件下，研究了具有不同昼夜肾上腺皮质节律的成年雄性大鼠之间相互影响的可能性。将完整大鼠和去眼球大鼠按不同比例一同饲养在同一笼中。每隔4小时分别测定血浆皮质酮水平的24小时或48小时模式。在昼夜明暗交替条件下，完整大鼠的昼夜节律始终与光照同步，而在与三只完整大鼠同笼的单只去眼球大鼠在整个15周的实验期间呈现自由运转节律。在持续光照下，完整大鼠和去眼球大鼠在前2周昼夜节律均自由运转。在第2周结束时，完整大鼠出现节律相位反转，去眼球大鼠在结合后5至8周出现节律相位反转。这些结果表明，即使两种类型的大鼠在同一笼中共同生活，完整大鼠和去眼球大鼠的昼夜肾上腺皮质节律也不会相互同步。
