大肠杆菌中对二氨基庚二酸和赖氨酸有需求的突变体的遗传分析。
Genetic analysis of diaminopimelic acid- and lysine-requiring mutants of Escherichia coli.
作者信息
Bukhari A I, Taylor A L
出版信息
J Bacteriol. 1971 Mar;105(3):844-54. doi: 10.1128/jb.105.3.844-854.1971.
Abstract
Several diaminopimelic acid (DAP)- and lysine-requiring mutants of Escherichia coli were isolated and studied by genetic, physiological, and biochemical means. The genes concerned with DAP-lysine synthesis map at several different sites on the E. coli chromosome and, therefore, do not constitute a single operon. Three separate loci affecting DAP synthesis are located in the 0 to 2.5 min region of the genetic map. The order of the loci in this region is thr-dapB-pyrA-ara-leu-pan-dapC-tonA-dapD. Two additional DAP genes map in the region between min 47 and 48, with the gene order being gua-dapA-dapE-ctr. The lys locus at min 55 determines the synthesis of the enzyme DAP decarboxylase, which catalyzes the conversion of DAP into lysine. The order of the genes in this region is serA-lysA-thyA.
摘要
分离出了几种需要二氨基庚二酸（DAP）和赖氨酸的大肠杆菌突变体，并通过遗传学、生理学和生物化学方法进行了研究。与DAP-赖氨酸合成相关的基因位于大肠杆菌染色体上的几个不同位点，因此，它们并不构成一个单一的操纵子。影响DAP合成的三个独立基因座位于遗传图谱的0至2.5分钟区域。该区域中基因座的顺序是thr-dapB-pyrA-ara-leu-pan-dapC-tonA-dapD。另外两个DAP基因位于47至48分钟之间的区域，基因顺序为gua-dapA-dapE-ctr。位于55分钟处的lys基因座决定了DAP脱羧酶的合成，该酶催化DAP转化为赖氨酸。该区域中基因的顺序是serA-lysA-thyA。
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