Kennedy J C, Treadwell P E, Lennox E S
J Exp Med. 1970 Aug 1;132(2):353-67. doi: 10.1084/jem.132.2.353.
A synergistic immune response to foreign erythrocytes may be induced in heavily irradiated mice injected with a mixture of isologous cells obtained from marrow and from the peritoneal cavity. Under appropriate conditions, homologous or heterologous peritoneal cavity cells, heat-killed cells, or cellfree extracts made from such cells are also effective. The activity of the peritoneal cavity cells or extracts is antigen-specific, in the sense that cells or extracts obtained from animals previously immunized with the test antigen produce much stronger synergistic effects than do cells from animals immunized with some other antigen; however, the peritoneal cavity cells or extracts are not immunogenic when tested in primed animals. The marrow cells, demonstrated to contain precursors of the antibody-forming cells produced during this synergistic immune response, also show a form of antigen-specificity.
给受到重度辐射的小鼠注射从骨髓和腹腔获得的同种细胞混合物，可能会诱导其对外源红细胞产生协同免疫反应。在适当条件下，同源或异源腹腔细胞、热灭活细胞或由此类细胞制成的无细胞提取物也有效。腹腔细胞或提取物的活性具有抗原特异性，即从先前用测试抗原免疫的动物获得的细胞或提取物比用其他抗原免疫的动物的细胞产生更强的协同效应；然而，在致敏动物中进行测试时，腹腔细胞或提取物没有免疫原性。骨髓细胞被证明含有在这种协同免疫反应过程中产生的抗体形成细胞的前体，也表现出一种抗原特异性形式。
