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噬菌体T2抗体的体外诱导：所用RNA提取物中的抗原

Induction in vitro of antibodies to phage T2: antigens in the RNA extract employed.

作者信息

Friedman H P, Stavitsky A B, Solomon J M

出版信息

Science. 1965 Sep 3;149(3688):1106-7. doi: 10.1126/science.149.3688.1106.

DOI:10.1126/science.149.3688.1106
PMID:5826525
Abstract

Cells from rat peritoneal exudate incubated in vitro with phage T2 yield RNA which induces cultures of rat lymph nodes to form antibodies. Complement fixation reveals T2 head, tail, and internal protein antigens in the RNA. Inoculating the RNA into mice that had previously been stimulated primarily with whole phage T2 results in a secondary response of neutralizing antibody.

摘要

将大鼠腹腔渗出液中的细胞与噬菌体T2在体外培养，可产生能诱导大鼠淋巴结培养物形成抗体的RNA。补体结合试验显示该RNA中存在T2头部、尾部和内部蛋白质抗原。将该RNA接种到先前先用完整噬菌体T2进行初次刺激的小鼠体内，会引发中和抗体的二次反应。

相似文献

1
Induction in vitro of antibodies to phage T2: antigens in the RNA extract employed.噬菌体T2抗体的体外诱导：所用RNA提取物中的抗原
Science. 1965 Sep 3;149(3688):1106-7. doi: 10.1126/science.149.3688.1106.
2
Studies on antibody induction in vitro. 3. Cellular requirements for the induction of antibody synthesis by solubilized T2 phage and immunogenic RNA.体外抗体诱导研究。3. 可溶性T2噬菌体和免疫原性RNA诱导抗体合成的细胞需求。
J Immunol. 1974 Jun;112(6):1981-6.
3
[Studies on the in vitro formation of antibodies. III. Induction of primary and secondary immune response in vitro].[抗体的体外形成研究。III. 体外诱导初次和二次免疫应答]
Z Immunitatsforsch Exp Klin Immunol. 1975 May;148(5):431-50.
4
Detection of anti-phage antibody by passive hemagglutination. II. Early antibodies produced in vivo or in vitro.通过被动血凝反应检测抗噬菌体抗体。II. 体内或体外产生的早期抗体
J Immunol. 1971 Oct;107(4):953-6.
5
[Intercellular information transfer in the process of immunogenesis. VI. The induction of antiphage antibody synthesis in the cells of rat transplantable lymphosarcoma under the influence of splenic RNA from rats and mice immunized with phage T2].[免疫发生过程中的细胞间信息传递。VI. 用噬菌体T2免疫的大鼠和小鼠的脾脏RNA影响下大鼠可移植性淋巴肉瘤细胞中抗噬菌体抗体合成的诱导]
Tsitologiia. 1979 Apr;21(4):452-8.
6
Studies on antibody induction in vitro. I. The nature of the primary response to soluble T2 antigens by rabbit spleen cells.体外抗体诱导的研究。I. 兔脾细胞对可溶性T2抗原的初次应答的性质。
J Immunol. 1973 Mar;110(3):811-9.
7
Neutralization of bacterial viruses by antibodies of young anomals. I. Dependence of neutralizing activity of 19 S and 7 S antibodies on complement in the course of the primary and secondary response of young rabbits immunized with T2 phage.幼龄动物抗体对细菌病毒的中和作用。I. 用T2噬菌体免疫的幼兔在初次和二次反应过程中，19S和7S抗体的中和活性对补体的依赖性。
Folia Microbiol (Praha). 1969;14(2):165-70. doi: 10.1007/BF02892886.
8
RNA in mouse cells exposed to different antigens.
Nature. 1968 Feb 24;217(5130):720-3. doi: 10.1038/217720a0.
9
Antibody response to bacteriophage theta-X 174 in vitro: demonstration of immunological memory in terms of IgM and IgG responses.体外针对噬菌体θ-X 174的抗体反应：根据IgM和IgG反应证明免疫记忆
Eur J Immunol. 1972 Aug;2(4):332-7. doi: 10.1002/eji.1830020407.
10
[Antibody synthesis in vitro. I. Specific stimulation of tissue culture by phage-receptor particles].[体外抗体合成。I. 噬菌体受体颗粒对组织培养的特异性刺激]
Z Med Mikrobiol Immunol. 1966;152(1):1-19.

引用本文的文献

1
Failure of synthetic polynucleotides to affect the immunogenicity of mycobacterial ribonucleic Acid and ribosomal protein preparations.合成多核苷酸不能影响分枝杆菌核糖核酸和核糖体蛋白制剂的免疫原性。
Infect Immun. 1971 Jan;3(1):149-53. doi: 10.1128/iai.3.1.149-153.1971.
2
A study of the passive transfer of delayed hypersensitivity to DNP-poly-L-lysine and DNP-GL in responder and nonresponder guinea pigs.一项关于迟发型超敏反应向应答和不应答豚鼠被动转移至二硝基苯基-聚-L-赖氨酸和二硝基苯基-球蛋白的研究。
J Exp Med. 1967 Nov 1;126(5):959-67. doi: 10.1084/jem.126.5.959.
3
Expermental salmonellosis. XI. Induction of cellular immunity and formation of antibody by transfer agent of mouse mononuclear phagocytes.
实验性沙门氏菌病。XI. 小鼠单核吞噬细胞转移因子诱导细胞免疫及抗体形成。
J Bacteriol. 1967 Oct;94(4):907-13. doi: 10.1128/jb.94.4.907-913.1967.
4
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
5
Primary antibody response in organ cultures.器官培养中的初次抗体反应。
J Exp Med. 1966 Nov 1;124(5):1001-16. doi: 10.1084/jem.124.5.1001.
6
The chemical nature of macrophage RNA-antigen complexes and their relevance to immune induction.巨噬细胞RNA-抗原复合物的化学性质及其与免疫诱导的相关性。
J Exp Med. 1969 Sep 1;130(3):557-74. doi: 10.1084/jem.130.3.557.
7
Immune responses in vitro. I. Cellular requirements for the immune response by nonprimed and primed spleen cells in vitro.体外免疫反应。I. 体外非致敏和致敏脾细胞免疫反应的细胞需求。
J Exp Med. 1969 Aug 1;130(2):345-64. doi: 10.1084/jem.130.2.345.
8
The detection of the cellular immune response against bacteriophage phi-X174 by an adaptation of the haemolytic plaque technique.通过改良溶血空斑技术检测针对噬菌体φ-X174的细胞免疫反应。
Immunology. 1968 Nov;15(5):661-70.
9
The interaction of human monocytes and lymphocytes.人类单核细胞与淋巴细胞的相互作用。
J Exp Med. 1968 Dec 1;128(6):1309-25. doi: 10.1084/jem.128.6.1309.
10
[Synthesis of antibodis in vitro. VII. On the action of informative RNA molecules in cell-free systems of spleen cells].
Z Med Mikrobiol Immunol. 1967;153(3):250-68.