Ziv G, Rasmussen F
J Dairy Sci. 1975 Jun;58(6):938-46. doi: 10.3168/jds.S0022-0302(75)84660-1.
In crossover trials, four lactating goats were given intramammary infusions and intramuscular injections of radioactivelabeled benzylpenicillin, spiramycin, chloramphenicol, dihydrostreptomycin, and tetracycline. Milk was collected after each treatment and the antibiotic contents in whole milk, skim milk, and whey were determined microbiologically and radiochemically and in cream and casein by radiochemical assay methods. Uptake of antibiotics by cream and casein was highly dependent on drug concentration, increasing with the decrease in antibiotic content in whole milk. Lipophilic chloramphenicol and tetracycline were concentrated in cream to a higher degree than the less lipophilic benzylpenicillin and dihydrostreptomycin. Antibiotic uptake by cream separated from whole milk after intramuscular injection was higher than after intramammary infusion. Antibiotic uptake by casein was independent of the route of administration and was highest for dihydrostreptomycin and tetracycline and lowest for benzylpenicillin.
在交叉试验中，对四只泌乳山羊进行了乳房内输注和肌肉注射放射性标记的苄青霉素、螺旋霉素、氯霉素、双氢链霉素和四环素。每次处理后收集牛奶，并通过微生物学、放射化学方法以及放射化学分析方法测定全脂牛奶、脱脂牛奶和乳清中的抗生素含量，以及奶油和酪蛋白中的抗生素含量。奶油和酪蛋白对抗生素的摄取高度依赖于药物浓度，并随着全脂牛奶中抗生素含量的降低而增加。亲脂性的氯霉素和四环素在奶油中的浓缩程度高于亲脂性较低的苄青霉素和双氢链霉素。肌肉注射后从全脂牛奶中分离出的奶油对抗生素的摄取高于乳房内输注后。酪蛋白对抗生素的摄取与给药途径无关，双氢链霉素和四环素的摄取最高，苄青霉素的摄取最低。
