Záruba K, Vejbora O, Chobola M
Clin Exp Immunol. 1971 Sep;9(3):399-405.
The development of experimental infection of the urinary tract was studied in previously sensitized, immunized and control rabbits after temporary ligature of the ureter and intravenous administration of various doses of . (1) After a small dose of organisms (200,000 ) positive bacteriuria became manifest in sensitized and immunized rabbits. In control rabbits, bacteriuria remained negative after this dose. (2)After a larger dose (200 million) positive bacteriuria became manifest sooner in sensitized rabbits. In the further course of the experiment, however, no differences were found in the intensity or the time of excretion of micro-organisms in the urine. Bacteriuria persisted for 12 weeks in sensitized, immunized and control rabbits. (3) The result of sensitization and immunization was controlled by means of skin and serological tests. Rabbits sensitized with an inactivated suspension showed positive skin tests and specific antibodies in the serum. In immunized rabbits, the skin tests were negative at the beginning of the experiment. Specific agglutinin titres were higher in the immunized rabbits than in the sensitized rabbits.
在对输尿管进行临时结扎并静脉注射不同剂量的……后，对先前致敏、免疫和对照兔的尿路感染实验发展情况进行了研究。（1）在注射小剂量微生物（200,000……）后，致敏兔和免疫兔出现了阳性菌尿。在此剂量下，对照兔的菌尿仍为阴性。（2）在注射较大剂量（2亿）后，致敏兔更早出现阳性菌尿。然而，在实验的后续过程中，尿液中微生物的排出强度或时间未发现差异。致敏兔、免疫兔和对照兔的菌尿持续了12周。（3）通过皮肤和血清学试验来控制致敏和免疫的结果。用灭活的……悬液致敏的兔皮肤试验呈阳性，血清中有特异性抗体。在免疫兔中，实验开始时皮肤试验为阴性。免疫兔的特异性凝集素滴度高于致敏兔。
