Med Lav. 2000 Nov-Dec;91(6):575-86.
The aim of this study was to evaluate the prevalence and major correlates of occupational exposure to asbestos among the 125 cases of mesothelioma of the pleura, peritoneum, and pericardium registered in the Romagna Region of Italy between 1986 and 1998. Adequate occupational information was obtained for 122 (98%) cases. Among these, the male:female ratio was 81:41 (2.0), the median age was 68 years (range, 25-92), and the pleural location accounted for 96 (79%) cases. According to job history, 61 (50%) cases had had definite (23), probable (12), and possible (26) occupational exposure to asbestos. The probability (multiple logistic regression estimate) was greater for males (odds ratio, 10.8) but decreased for cases with mesothelioma of the peritoneum and pericardium (0.21) as well as those above the median age (0.38). Time period, residence, mode of diagnosis (histology, cytology, other), source of information (patient, wife/husband, others), and smoking habits exerted no independent effect. For 35 (57%) cases, occupational exposure was related to asbestos pollution of the workplace and not to the specific work task. Cases with definite, probable, and possible occupational exposure showed no significant difference in the distribution (Kruskal-Wallis test) by year of initial employment at risk, duration of exposure, and latency (median, 36 years). Occupational exposure occurred in a total of 22 workplaces. Three of these accounted for 21 (34%) cases. Multiple (> or = 2) cases (total 27 or 44%) were observed in six workplaces.
本研究的目的是评估1986年至1998年期间在意大利罗马涅地区登记的125例胸膜、腹膜和心包间皮瘤病例中职业性接触石棉的患病率及主要相关因素。获得了122例（98%）病例的充分职业信息。其中，男女比例为81:41（2.0），中位年龄为68岁（范围25 - 92岁），胸膜部位占96例（79%）。根据工作史，61例（50%）病例有明确（23例）、可能（12例）和疑似（26例）职业性接触石棉的情况。男性的可能性（多元逻辑回归估计）更大（优势比为10.8），但腹膜和心包间皮瘤病例（0.21）以及年龄高于中位数的病例（0.38）的可能性降低。时间段、居住地、诊断方式（组织学、细胞学、其他）、信息来源（患者、妻子/丈夫、其他人）和吸烟习惯均无独立影响。对于35例（57%）病例，职业性接触与工作场所的石棉污染有关，而与具体工作任务无关。有明确、可能和疑似职业性接触的病例在首次面临风险的就业年份、接触持续时间和潜伏期（中位数36年）的分布（Kruskal - Wallis检验）上无显著差异。职业性接触共发生在22个工作场所。其中3个工作场所占21例（34%）。在6个工作场所观察到多例（≥2例）病例（共27例，占44%）。
