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[神经症的差异药物治疗(苯二氮䓬衍生物的比较疗效)]

[Differential pharmacotherapy of neurotic conditions (comparative effectiveness of benzodiazepine derivatives)].

作者信息

Smulevich A B, Mazaeva N A, Golovanova L A, Dubnitskaia E B

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1976;76(2):255-62.

PMID:4938
Abstract

The effectiveness in treating borderline states to a certain degree depends upon the pole (sthenic or asthenic) of the corresponding disturbance. Tranquilizers are the preparations of choice in the treatment of disorders of an asthenic pole (psychopathy of the asthenic range, neurotic states). In borderline conditions of a sthenic pole the effectiveness of tranquilizers is equal or sometimes is even less than in therapy with small doses of neuroleptics. In treating neurotic conditions tranquilizers of the benzodiazepine group can be ranged in the following succession: nitrazepam, chlordiazepoxide, medazepam, oxazepam, diazepam, lorazepam. This preparation is a continuun of an increasing psychotropic activity.

摘要

在一定程度上,治疗边缘状态的有效性取决于相应障碍的极点(亢进或虚弱)。镇静剂是治疗虚弱极点障碍(虚弱型精神病变、神经症状态)的首选制剂。在亢进极点的边缘状态下,镇静剂的有效性等同于或有时甚至低于小剂量抗精神病药物治疗的有效性。在治疗神经症状态时,苯二氮䓬类镇静剂可按以下顺序排列:硝西泮、氯氮䓬、美达西泮、奥沙西泮、地西泮、劳拉西泮。这种制剂的精神活性呈递增趋势。

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