Manicourt D, Orloff S, Rao V H
Scand J Rheumatol. 1979;8(3):161-7. doi: 10.3109/03009747909114449.
In rheumatoid arthritis (RA) the synovial fluid lymphocyte count closely parallels the synovial fluid dialysable hydroxyproline, a marker of collagen resorption. This observation stresses the primordial role of lymphocytes in RA joint injury. The actual and eventually potential destruction of any single joint, as expressed by synovial fluid dialysable hydroxyproline levels, seems to reflect the general picture of disease activity as evaluated by the number of active joints (joint count), ESR and rheumatoid factor titres (latex fixation). Although urinary hydroxyproline levels are generally within the normal range in RA, they can be used as index of articular tissue destruction and as a parameter of overall disease activity when groups of patients are studied longitudinally in detail. The present study sheds no further light on the significance of synovial fluid and blood non-dialysable hydroxyproline levels.
在类风湿性关节炎（RA）中，滑膜液淋巴细胞计数与滑膜液可透析羟脯氨酸密切平行，可透析羟脯氨酸是胶原蛋白吸收的一个标志物。这一观察结果强调了淋巴细胞在RA关节损伤中的首要作用。任何单个关节的实际以及最终潜在破坏，如通过滑膜液可透析羟脯氨酸水平所表达的，似乎反映了通过活动关节数量（关节计数）、血沉和类风湿因子滴度（乳胶凝集试验）评估的疾病活动总体情况。虽然RA患者的尿羟脯氨酸水平通常在正常范围内，但当对患者群体进行详细的纵向研究时，它们可用作关节组织破坏的指标以及总体疾病活动的参数。本研究并未进一步阐明滑膜液和血液中不可透析羟脯氨酸水平的意义。
