精氨酸生物合成前体对大肠杆菌精氨酰 - 转移核糖核酸合成酶活性的抑制作用。
Inhibition of arginyl-transfer ribonucleic acid synthetase activity of Escherichia coli by arginine biosynthetic precursors.
作者信息
Yem D W, Williams L S
出版信息
J Bacteriol. 1971 Aug;107(2):589-91. doi: 10.1128/jb.107.2.589-591.1971.
Abstract
The arginine biosynthetic precursors, ornithine, citrulline, and argininosuccinate, inhibit arginyl-transfer ribonucleic acid (tRNA) synthetase (EC 6.1.1.13, arginine: soluble RNA ligase, adenosine monophosphate) activity in the in vitro attachment assay system. Ornithine is the most potent, argininosuccinate is next, and citrulline is least effective. The implications of these results are discussed in relation to arginyl-tRNA synthetase activity and the level of the arginine biosynthetic enzymes during conditions of restricted and unrestricted supply of arginine to cells.
摘要
精氨酸生物合成前体鸟氨酸、瓜氨酸和精氨琥珀酸在体外连接测定系统中抑制精氨酰转移核糖核酸（tRNA）合成酶（EC 6.1.1.13，精氨酸：可溶性RNA连接酶，单磷酸腺苷）的活性。鸟氨酸的抑制作用最强，精氨琥珀酸次之，瓜氨酸的作用最不明显。结合细胞在精氨酸供应受限和不受限条件下精氨酰-tRNA合成酶的活性以及精氨酸生物合成酶的水平，对这些结果的意义进行了讨论。
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