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胶原蛋白的免疫原性与特异性。十二、用免疫荧光法和血细胞凝集法证明对人胶原蛋白具有不同特异性的抗体

Immunogenicity and specificity of collagen. XII. Demonstration by immunofluorescence and haemagglutination of antibodies with different specificity to human collagen.

作者信息

Steffen C, Dichtl M, Knapp W, Brunner H

出版信息

Immunology. 1971 Oct;21(4):649-57.

PMID:4941375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1408234/
Abstract

A comparative investigation, using haemagglutination, haemagglutination-inhibition and immunofluorescence, was performed for demonstration of antibodies with different types of collagen specificity. In rabbit antisera to acid-soluble human collagen a fraction of species-specific antibodies to human collagen and a fraction of general, non-species-specific collagen antibodies could be demonstrated in good accordance by both techniques. Calf, rabbit, rat and guinea-pig collagen were used as heterologous control preparations.

摘要

采用血凝、血凝抑制和免疫荧光技术进行了一项比较研究，以证明具有不同类型胶原特异性的抗体。在兔抗酸溶性人胶原血清中，两种技术均能很好地证明存在一部分针对人胶原的种属特异性抗体和一部分通用的、非种属特异性的胶原抗体。使用小牛、兔、大鼠和豚鼠胶原作为异源对照制剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7de7/1408234/010f586e29c2/immunology00357-0100-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7de7/1408234/dae5491b03a9/immunology00357-0099-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7de7/1408234/010f586e29c2/immunology00357-0100-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7de7/1408234/dae5491b03a9/immunology00357-0099-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7de7/1408234/010f586e29c2/immunology00357-0100-a.jpg

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Immunogenicity and specificity of collagen. XII. Demonstration by immunofluorescence and haemagglutination of antibodies with different specificity to human collagen.胶原蛋白的免疫原性与特异性。十二、用免疫荧光法和血细胞凝集法证明对人胶原蛋白具有不同特异性的抗体
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2
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Ann Rheum Dis. 2018 Sep;77(9):1345-1353. doi: 10.1136/annrheumdis-2017-212627. Epub 2018 Jun 12.
2
[Demonstration of antibodies with different collagen specificity in progressive chronic polyarthritis and comparison of human collagen and calf collagen as test antigen].[进行性慢性多关节炎中不同胶原特异性抗体的展示以及人胶原和小牛胶原作为测试抗原的比较]
Klin Wochenschr. 1973 Mar 1;51(5):222-9. doi: 10.1007/BF01467771.
3

本文引用的文献

1
[Studies on the significance of collagen in rheumatism serology].[关于胶原蛋白在风湿病血清学中的意义的研究]
Z Rheumaforsch. 1962 Dec;21:417-41.
2
Antigenicity of rat collagen. Demonstration of antibody to rat collagen in the renal glomeruli of rats by fluorescence microscopy.大鼠胶原蛋白的抗原性。通过荧光显微镜在大鼠肾小球中证明针对大鼠胶原蛋白的抗体。
J Exp Med. 1961 Jun 1;113(6):1041-51. doi: 10.1084/jem.113.6.1041.
3
The serologic specificity of tropocollagen telopeptides.原胶原蛋白端肽的血清学特异性。
Antibodies against heterologous connective-tissue cells in rheumatic fever.
风湿热中针对异源结缔组织细胞的抗体。
Bull Exp Biol Med. 1974 Dec;77(6):666-9. doi: 10.1007/BF00789997.
4
Induction of acute and chronic arthritis by intra-articular injection of preformed collagen-anticollagen complexes.通过关节内注射预先形成的胶原蛋白 - 抗胶原蛋白复合物诱导急性和慢性关节炎。
Immunology. 1977 Feb;32(2):161-70.
J Exp Med. 1967 Aug 1;126(2):331-46. doi: 10.1084/jem.126.2.331.
4
[Further studies on collagen antibodies in patients with primary chronic polyarthritis].[原发性慢性多关节炎患者胶原抗体的进一步研究]
Klin Wochenschr. 1968 Sep 15;46(18):976-81. doi: 10.1007/BF01745585.
5
Immunogenicity and specificity of collagen. VI. Separation of antibody fractions with restricted specificity from anti-collagen sera using an immunoadsorbent technique.胶原蛋白的免疫原性与特异性。VI. 使用免疫吸附技术从抗胶原蛋白血清中分离具有受限特异性的抗体组分。
Immunology. 1968 Jul;15(1):145-51.
6
[Studies on the autoantibody properties of collagen antibodies and their occurrence in the synovia of patients with rheumatoid arthritis].[胶原蛋白抗体的自身抗体特性及其在类风湿性关节炎患者滑膜中的出现情况研究]
Z Rheumaforsch. 1971 Mar-Apr;30(3):92-7.
7
Immunologic relations among various animal collagens.各种动物胶原蛋白之间的免疫关系。
J Exp Med. 1965 Sep 1;122(3):441-54. doi: 10.1084/jem.122.3.441.
8
Conjugation of fluorescein isothiocyanate to antibodies. II. A reproducible method.异硫氰酸荧光素与抗体的结合。II. 一种可重复的方法。
Immunology. 1970 Jun;18(6):875-81.
9
Immunogenicity and specificity of collagen. V. Demonstration of three different antigenic determinants on calf collagen.胶原蛋白的免疫原性与特异性。V. 小牛胶原蛋白上三种不同抗原决定簇的证明
Immunology. 1968 Jul;15(1):135-44.
10
Demonstration by immunofluorescence of the fixation of perfused antibody to human collagen in human kidney.通过免疫荧光法证实灌注抗体在人肾中与人胶原蛋白的结合。
J Exp Med. 1967 Apr 1;125(4):595-606. doi: 10.1084/jem.125.4.595.