各种动物胶原蛋白之间的免疫关系。
Immunologic relations among various animal collagens.
作者信息
Rothbard S, Watson R F
出版信息
J Exp Med. 1965 Sep 1;122(3):441-54. doi: 10.1084/jem.122.3.441.
Abstract
By the use of complement fixation and in vivo immunofluorescence with cross-absorption studies it was shown that acid soluble collagens prepared from rat, mouse, guinea pig, chicken, carp, and man exhibit species specificity. Rat and mouse collagens were found to be indistinguishable and to cross-react with guinea pig collagen. Cross-reactions also occurred between the collagens of rat and man and chicken and man. Tissue specificity, or an antigen common to all of the collagens, was not demonstrated. There was complete agreement in the results of the two immunologic methods. The findings in this study support the conclusion that collagen in some form is present in the renal glomerular basement membranes.
摘要
通过补体结合试验以及交叉吸收研究的体内免疫荧光试验表明，从大鼠、小鼠、豚鼠、鸡、鲤鱼和人类制备的酸溶性胶原蛋白具有种属特异性。发现大鼠和小鼠的胶原蛋白无法区分，并且与豚鼠胶原蛋白发生交叉反应。大鼠与人类、鸡与人类的胶原蛋白之间也发生了交叉反应。未证实存在组织特异性或所有胶原蛋白共有的抗原。两种免疫学方法的结果完全一致。本研究中的发现支持以下结论：某种形式的胶原蛋白存在于肾小球基底膜中。
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