Mejía-Laguna J E, Martínez-Palomo A, López-Soriano F, García-Cornjeo M, Biro C E
Immunology. 1971 Dec;21(6):879-82.
Rabbits rendered leucopenic by means of nitrogen mustard reject kidney xenografts more slowly than normal controls It is therefore probable that polymorphonuclear leucocytes play an important role in the acute rejection of xenografts. The previously reported complement requirement for xenograft rejection was also confirmed in this work, by depleting the graft recipients of C3 with cobra venom factor.
用氮芥使家兔出现白细胞减少后,其对肾异种移植的排斥比正常对照组更为缓慢。因此,多形核白细胞很可能在异种移植的急性排斥中起重要作用。在这项研究中,通过用眼镜蛇毒因子使移植受体的C3耗竭,也证实了先前报道的异种移植排斥对补体的需求。