Wideröe R
Strahlentherapie. 1979 Oct;155(10):666-72.
Today a change from the orthodox "200 rad daily, 5 times per week" scheme to other improved treatment schemes is in the foreground of discussions. However, the situation is very complex and so far no distinct solution has been found. Radiobiology has recommended larger doses at less frequent intervals, but also smaller doses given more often have been used with quite good results. Several factors are important: Tumor conditions, dimensions, growth and sensitivity--reoxygenation of hypoxic tumor cells--recovery and tolerance of normal cells and, last but not least, the general state of the patient. To explain and unravel the problems an example of therapy with high-energy electrons is described. Considering four fundamental successively depending decisions an empirical system is described which may enable us to find improved treatment schemes. Finally a method is explained which makes it possible to transform a treatment scheme to a different equivalent scheme by calculating a total effective standard dose (ESD). This calculation follows exactly the isoeffect principle and makes possible a comparison of different treatment schemes using also different types of radiation.
如今，从传统的“每日200拉德，每周5次”方案转变为其他改进的治疗方案成为了讨论的焦点。然而，情况非常复杂，迄今为止尚未找到明确的解决方案。放射生物学建议采用间隔时间更长的较大剂量，但更频繁给予的较小剂量也已被使用且效果相当不错。有几个因素很重要：肿瘤状况、大小、生长情况和敏感性——缺氧肿瘤细胞的再氧合——正常细胞的恢复和耐受性，以及最后但同样重要的患者的总体状况。为了解释和阐明这些问题，描述了一个高能电子治疗的例子。考虑四个依次相关的基本决策，描述了一个经验系统，该系统可能使我们找到改进的治疗方案。最后解释了一种方法，通过计算总有效标准剂量（ESD），可以将一种治疗方案转换为不同的等效方案。这种计算完全遵循等效效应原则，并使得使用不同类型辐射的不同治疗方案之间的比较成为可能。
