Glanzmann C, Horst W, Grossenbacher R, Fisch U
Strahlentherapie. 1979 Jul;155(7):451-6.
Results of radiotherapy alone or in combination with surgery in 215 patients with laryngeal cancer are reported (treatment time between 1963 and 1976). In patients with glottic cancer, the cure rate is about 80% and surgical treatment for persistent/recurrent cancer was necessary only in a few cases. Analysis of tumor dose, tumor control rate and complication rate shows that in cases with glottic cancer a tumor dose between 1900 and 2000 ret is necessary and tolerable. In patients with supraglottic laryngeal cancer, the cure rate is about 55%. Early stages (T1N0M0) were mostly treated by radiotherapy alone, moderately advanced stages (T1N1,T2N0+1) mostly received radiotherapy as a primary treatment and were operated in case of irradiation failure. Advanced stages were primarily treated by a combined therapy, and by radiotherapy alone if they were inoperable. In early cases, who are to be treated by radiotherapy alone, the tumor dose should be about 1900 ret. In moderate cases, treatment by primary irradiation alone is possible, if the patient can be followed up regularly; surgery is indicated, if the patient cannot unequivocally be classified as symptomless. In some of these cases, there is no tumor demonstrable histologically in the excised larynx. In using this treatment policy, there is a better functional treatment result than in using primary combined treatment in moderately advanced cases with supraglottic laryngeal cancer.
报告了215例喉癌患者单纯放疗或放疗联合手术的结果(治疗时间为1963年至1976年)。声门癌患者的治愈率约为80%,仅少数病例需要对持续性/复发性癌症进行手术治疗。肿瘤剂量、肿瘤控制率和并发症率分析表明,声门癌病例中1900至2000拉德的肿瘤剂量是必要且可耐受的。声门上喉癌患者的治愈率约为55%。早期阶段(T1N0M0)大多仅接受放疗,中度晚期阶段(T1N1、T2N0 + 1)大多以放疗作为主要治疗方法,若放疗失败则进行手术。晚期阶段主要采用联合治疗,若无法手术则仅进行放疗。对于仅需放疗的早期病例,肿瘤剂量应为约1900拉德。在中度病例中,如果患者能够定期随访,则仅进行初次放疗是可行的;如果患者不能明确归类为无症状,则建议进行手术。在其中一些病例中,切除的喉部组织学检查未发现肿瘤。采用这种治疗策略,与声门上喉癌中度晚期病例采用初次联合治疗相比,功能治疗效果更好。