Morfin R, Guiraud J M, Ducouret B, Samperez S, Jouan P
C R Seances Acad Sci D. 1979 Jan 29;288(4):437-40.
Incubation of 3H-5 alpha-androstane-3 beta, 17 beta-diol with anterior pituitaries from immature male Rats led to the major production of polar radio-metabolites. Of these, 53 and 27% were identified with 5 alpha-androstane-3 beta, 6 alpha, 17 beta-triol and 5 alpha-androstane-3 beta, 7 alpha, 17 beta-triol, respectively. The formation of these trihydroxysteroids may be involved in the intracellular regulation of 5 alpha-androstane-3 beta, 17 beta-diol levels.
将3H - 5α - 雄甾烷 - 3β, 17β - 二醇与未成熟雄性大鼠的垂体前叶一起孵育，导致主要产生极性放射性代谢物。其中，分别有53%和27%被鉴定为5α - 雄甾烷 - 3β, 6α, 17β - 三醇和5α - 雄甾烷 - 3β, 7α, 17β - 三醇。这些三羟基甾体的形成可能参与了5α - 雄甾烷 - 3β, 17β - 二醇水平的细胞内调节。
