Corpéchot C, Robel P, Axelson M, Sjövall J, Baulieu E E
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4704-7. doi: 10.1073/pnas.78.8.4704.
Dehydroepiandrosterone (3 beta-hydroxy-5-androsten-17-one, I) sulfate (Ia) has been characterized in the anterior and the posterior parts of the brain of adult male rats. Its level (1.58 +/- 0.14 and 4.89 +/- 1.06 ng/g, mean +/- SD, in anterior and posterior brain, respectively) largely exceeded that of I in brain (0.42 +/- 0.10 and 0.12 +/- 0.03 ng/g in anterior and posterior brain, respectively) and of Ia in plasma (0.26 +/- 0.13 ng/ml). Brain Ia level did not seem to depend on adrenal secretion; it was unchanged after administration of corticotropin or dexamethasone for 3 days, and no meaningful change occurred in brain 15 days after adrenalectomy plus orchiectomy, compared with sham-operated controls. In contrast, stress conditions prevailing 2 days after adrenalectomy plus orchiectomy or after the corresponding sham operation resulted in a significantly increased concentration of Ia in the brain. Changes of Ia level in brain occurred irrespective of changes in corresponding plasma samples. It is proposed that Ia formation or accumulation (or both) in the rat brain depends on in situ mechanisms unrelated to the peripheral endocrine gland system.
硫酸脱氢表雄酮（3β-羟基-5-雄烯-17-酮，I）硫酸盐（Ia）已在成年雄性大鼠大脑的前部和后部得到鉴定。其水平（在前脑和后脑分别为1.58±0.14和4.89±1.06 ng/g，平均值±标准差）大大超过了大脑中I的水平（在前脑和后脑分别为0.42±0.10和0.12±0.03 ng/g）以及血浆中Ia的水平（0.26±0.13 ng/ml）。大脑Ia水平似乎不依赖于肾上腺分泌；在给予促肾上腺皮质激素或地塞米松3天后其水平未发生变化，并且与假手术对照组相比，在肾上腺切除加睾丸切除术后15天大脑中也未出现有意义的变化。相反，在肾上腺切除加睾丸切除术后2天或相应假手术后出现的应激状态导致大脑中Ia浓度显著升高。大脑中Ia水平的变化与相应血浆样本的变化无关。有人提出，大鼠大脑中Ia的形成或积累（或两者兼有）取决于与外周内分泌腺系统无关的原位机制。
