Bischoff W, Pelz K, Klose A
Urol Int. 1979;34(5):356-62. doi: 10.1159/000280281.
In 7 dogs renal arterial embolization was performed using the Seldinger technique and an inflatable Swan Ganz balloon catheter. Methyl methacrylate and butyl-2-cyanoacrylate were injected. 6 months later, the tissue concentration of Cefazolin was measured in the embolized and contralateral kidneys and in serum 2 h after a short infusion of 1 h Cefazolin. The concentrations in serum and homogenized kidney tissue were determined by means of the agar gel diffusion method. Angiography showed no vessels in the embolized kidneys. Histologically there was total atrophy of the tissue, especially of the tubular system. The mean tissue level of Cefazolin in the embolized kidney was 70% of serum. The tissue concentration was always above 10 micrograms/g. This concentration is high enough to inhibit nearly all strains of E. coli, Klebsiella, Salmonella, Shigella and a large part of Proteus mirabilis, whereas nearly all gram-positive bacteria are inhibited at a lower concentration. The value and necessity of antibiotic therapy in embolized kidney cancer is discussed.
对7只犬采用Seldinger技术和可充气的Swan Ganz球囊导管进行肾动脉栓塞。注入了甲基丙烯酸甲酯和丁基-2-氰基丙烯酸酯。6个月后，在短时间输注1小时头孢唑林后2小时，测量栓塞肾和对侧肾以及血清中头孢唑林的组织浓度。血清和匀浆肾组织中的浓度通过琼脂凝胶扩散法测定。血管造影显示栓塞肾无血管。组织学检查显示组织完全萎缩，尤其是肾小管系统。栓塞肾中头孢唑林的平均组织水平为血清的70%。组织浓度始终高于10微克/克。该浓度足以抑制几乎所有大肠杆菌、克雷伯菌、沙门菌、志贺菌菌株以及大部分奇异变形杆菌，而几乎所有革兰氏阳性菌在较低浓度下即被抑制。讨论了栓塞性肾癌中抗生素治疗的价值和必要性。
