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多凝集红细胞和癌细胞上T抗原的表达:T激活红细胞、抗T凝集素、抗T吸附人血清及纯化抗T抗体的制备

Expression of T-antigen on polyagglutinable erythrocytes and carcinoma cells: preparation of T-activated erythrocytes, anti-T lectin, anti-T absorbed human serum and purified anti-T antibody.

作者信息

Howard D R

出版信息

Vox Sang. 1979;37(2):107-10. doi: 10.1111/j.1423-0410.1979.tb02279.x.

Abstract

Recent interest has been revived in the human MN blood group system due to the discovery of the MN precursor substance (T-antigen) on certain malignant, but not benign or normal tissues. Methods for preparing T-activated erythrocytes, anti-T lectin, anti-T absorbed human serum and purified anti-T antibody are described and should be useful not only to the researcher involved in this new line of investigation, but also to the routine blood bank faced with the occasional problem of erythrocyte polyagglitinability.

摘要

由于在某些恶性组织而非良性或正常组织上发现了MN前体物质(T抗原),人类MN血型系统最近重新引起了人们的关注。本文描述了制备T激活红细胞、抗T凝集素、抗T吸收人血清和纯化抗T抗体的方法,这些方法不仅对参与这一新研究领域的研究人员有用,而且对偶尔遇到红细胞多凝集性问题的常规血库也有用。

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