Sasaki T, Hattori T, Mayumi M
Vox Sang. 1979;37(4):216-21. doi: 10.1111/j.1423-0410.1979.tb02294.x.
During September and October of 1977, a total of 342,407 apparently healthy blood donors were screen for HBsAG by reversed PHA, and 6,342 (1.9%) asymptomatic carriers of HBV were identified. Prevalence of HBeAG and anti-HBe among HBV carriers was tested by our immunodiffusion method after serum samples had been concentrated threefold. The results were evaluated with reference to sex and age of donors, as well as HBsAG titre and s-GPT level in the serum. HBeAG was found slightly but significantly more often in male donors than in female donors (19.1 vs. 16.7%). In contrast, anti-HBe was found less frequently in males than in females (49.6 vs. 53.1%). Frequency of HBeAG decreased, while frequency of anti-HBe increased with age both in male and female carriers. The prevalence of HBeAG increased in parallel with the titre of HBsAG, whereas the prevalence of anti-HBe was approximately reciprocal to it. An abnormally high value of s-GPT (41 KARMEN U/ml or more) was found in 10.0% of the carriers with HBeAG, contrasting with 3.4% of those with anti-HBe.
1977年9月至10月期间，采用反向PHA法对总共342,407名表面健康的献血者进行了乙肝表面抗原（HBsAG）筛查，共识别出6,342名（1.9%）无症状乙肝病毒（HBV）携带者。血清样本浓缩三倍后，采用免疫扩散法检测HBV携带者中HBe抗原（HBeAG）和抗-HBe的流行情况。根据献血者的性别、年龄以及血清中HBsAG滴度和谷丙转氨酶（s-GPT）水平对结果进行评估。发现男性献血者中HBeAG的检出率略高于女性，但差异有统计学意义（19.1%对16.7%）。相反，男性中抗-HBe的检出率低于女性（49.6%对53.1%）。男性和女性携带者中，HBeAG的频率随年龄降低，而抗-HBe的频率随年龄增加。HBeAG的流行率与HBsAG滴度平行增加，而抗-HBe的流行率与之大致相反。10.0%的HBeAG携带者谷丙转氨酶（s-GPT）值异常高（41卡门单位/毫升或更高），而抗-HBe携带者中这一比例为3.4%。
