世界卫生组织协调了一项使用沙利度胺治疗男性瘤型麻风患者急性麻风反应的短期双盲试验。
WHO co-ordinated short-term double-blind trial with thalidomide in the treatment of acute lepra reactions in male lepromatous patients.
作者信息
Iyer C G, Languillon J, Ramanujam K, Tarabini-Castellani G, De las Aguas J T, Bechelli L M, Uemura K, Martinez Dominguez V, Sundaresan T
出版信息
Bull World Health Organ. 1971;45(6):719-32.
The treatment of lepra reactions constitutes one of the most serious problems in leprosy. For this reason, the first reports in 1965 of the favourable results obtained with thalidomide aroused considerable interest and led WHO, in 1967, to carry out a trial with the co-operation of four centres. A short-term double-blind trial was designed to study the effect of thalidomide, in comparison with acetylsalicylic acid, in the treatment of acute lepra reactions in male lepromatous patients. Acetylsalicylic acid was used instead of a placebo because of its antipyretic and analgesic activity. Because of the severe adverse reactions that may be caused by thalidomide, mainly the teratogenic effects, only males were included in the trial.The results of this short-term study seem to confirm previous reports of the efficacy of thalidomide and indicate that acetylsalicylic acid also seems to be helpful in the management of certain symptoms of lepra reactions.
麻风反应的治疗是麻风病中最严重的问题之一。因此，1965年首次报道沙利度胺取得的良好疗效引起了广泛关注，并促使世界卫生组织于1967年在四个中心的合作下开展了一项试验。设计了一项短期双盲试验，以研究沙利度胺与乙酰水杨酸相比，在治疗男性瘤型麻风急性麻风反应中的效果。由于乙酰水杨酸具有解热和镇痛作用，因此用它代替了安慰剂。由于沙利度胺可能会引起严重的不良反应，主要是致畸作用，所以试验仅纳入了男性。这项短期研究的结果似乎证实了先前关于沙利度胺疗效的报道，并表明乙酰水杨酸在麻风反应某些症状的处理中似乎也有帮助。
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