氟烷麻醉对大鼠脑氧消耗的影响。
The effect of halothane anaesthesia upon cerebral oxygen consumption in the rat.
作者信息
Harp J R, Nilsson L, Siesjö B K
出版信息
Acta Anaesthesiol Scand. 1976;20(1):83-90. doi: 10.1111/j.1399-6576.1976.tb05013.x.
The influence of halothane (0.6 and 2%) upon cerebral (cortical) blood flow (CBF) and cerebral metabolic rate for oxygen (CMRo2) was studied in artificially ventilated rats, using a modified technique of Kety & Schmidt (1948). The values obtained in halothane anaesthesia were compared to those recorded in nitrous oxide anaesthesia, or to those measured in unanesthetized animals given an analgesic drug (fentanyl citrate). Although it could be confirmed that halothane induces vasodilatation in the brain, there were relatively small differences in CBF between the groups. The results demonstrate that, in the rat, halothane depresses CMRo2 in a dose-dependent way. With 0.6% halothane, CMRo2 was reduced by 20-30% and, with 2% halothane, CMRo2 was reduced by about 50%. Thus, in the rat the effect of 2% halothane upon metabolic rate is comparable to that observed in barbiturate anaesthesia.
采用Kety和Schmidt（1948年）改良技术，在人工通气的大鼠中研究了氟烷（0.6%和2%）对脑（皮质）血流量（CBF）和脑氧代谢率（CMRo2）的影响。将氟烷麻醉下获得的值与氧化亚氮麻醉下记录的值，或与给予镇痛药物（枸橼酸芬太尼）的未麻醉动物中测量的值进行比较。尽管可以证实氟烷可诱导脑血管舒张，但各组之间的CBF差异相对较小。结果表明，在大鼠中，氟烷以剂量依赖性方式降低CMRo2。使用0.6%氟烷时，CMRo2降低20%-30%，使用2%氟烷时，CMRo2降低约50%。因此，在大鼠中，2%氟烷对代谢率的影响与巴比妥类麻醉中观察到的相当。
Zotero 插件