球状附红细胞体。一、对小鼠干扰素反应的影响
Eperythrozoon coccoides. I. Effect on the interferon response in mice.
作者信息
Glasgow L A, Odugbemi T, Dwyer P, Ritterson A L
出版信息
Infect Immun. 1971 Oct;4(4):425-30. doi: 10.1128/iai.4.4.425-430.1971.
Abstract
Eperythrozoon coccoides is a common blood parasite of rodents and the etiological agent of a chronic infection present in many mouse colonies. After primary infection, mice develop a parasitemia and anemia followed by a chronic, latent infection. During the acute phase of infection, mice manifest a striking suppression of interferon production in response to induction with Newcastle disease virus, Chikungunya virus, and poly I:C. These data suggest that the reticuloendothelial system involvement with this agent is associated with impairment of the interferon response. The enhanced susceptibility of E. coccoides-infected animals to certain viral infections may be related to this suppression of interferon production.
摘要
球状附红细胞体是啮齿动物常见的血液寄生虫，也是许多小鼠群体中慢性感染的病原体。初次感染后，小鼠会出现寄生虫血症和贫血，随后进入慢性潜伏感染阶段。在感染的急性期，小鼠在受到新城疫病毒、基孔肯雅病毒和聚肌胞苷酸诱导后，干扰素产生受到显著抑制。这些数据表明，网状内皮系统与该病原体的相互作用与干扰素反应受损有关。球状附红细胞体感染动物对某些病毒感染易感性增强可能与此处干扰素产生受抑制有关。
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