痤疮丙酸杆菌对小鼠干扰素产生的影响。
Effect of Corynebacterium acnes on interferon production in mice.
作者信息
Farber P A, Glasgow L A
出版信息
Infect Immun. 1972 Sep;6(3):272-6. doi: 10.1128/iai.6.3.272-276.1972.
Abstract
Exposure to Corynebacterium acnes, the most prominent member of our normal skin flora, produces stimulation of lymphoid tissue and certain reticuloendothelial system functions, as well as the immune response. Alteration of the host response is extended by these studies to include changes in the pattern of interferon production in response to a representative group of inducing agents. Serum interferon levels induced by the injection of endotoxin in mice are enhanced, whereas interferon production after injection of Newcastle disease virus, Chikungunya virus, and polyinosinic:polycytidylic acid is depressed in animals inoculated with viable or nonviable C. acnes organisms.
摘要
暴露于痤疮丙酸杆菌（我们正常皮肤菌群中最主要的成员）会刺激淋巴组织和某些网状内皮系统功能以及免疫反应。这些研究将宿主反应的改变扩展到包括对一组代表性诱导剂产生反应时干扰素产生模式的变化。给小鼠注射内毒素诱导的血清干扰素水平会升高，而在接种了活的或灭活的痤疮丙酸杆菌的动物中，注射新城疫病毒、基孔肯雅病毒和聚肌苷酸:聚胞苷酸后干扰素的产生会受到抑制。
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