Covert J B, Zarkower A
Infect Immun. 1971 Oct;4(4):452-5. doi: 10.1128/iai.4.4.452-455.1971.
Mice were injected intraperitoneally with 50 mug of Escherichia coli lipopolysaccharide (LPS). The spleen tissue exhibited increased histamine-forming capacity (HFC) 4 hr later. When this increased HFC was produced within 12 hr after intraperitoneal injection of sheep red blood cells (SRBC), there was an enhanced anti-SRBC antibody response in the spleen. In mice experiencing an increased spleen HFC at 36 hr after injection of SRBC, there was a significant decrease in the number of antibody-producing cells. The injection of histidine decarboxylase inhibitors simultaneously with the LPS greatly reduced the stimulation of HFC and also the adjuvant activity of the LPS.
给小鼠腹腔注射50微克大肠杆菌脂多糖（LPS）。4小时后，脾脏组织的组胺生成能力（HFC）增强。当在腹腔注射绵羊红细胞（SRBC）后12小时内产生这种增强的HFC时，脾脏中抗SRBC抗体反应增强。在注射SRBC后36小时脾脏HFC增加的小鼠中，抗体产生细胞的数量显著减少。与LPS同时注射组氨酸脱羧酶抑制剂可大大降低HFC的刺激以及LPS的佐剂活性。
