Lazaroni F A, Chiocca J C, Salis G B, Mazure P A
Acta Gastroenterol Latinoam. 1979;9(1):15-22.
In 10 patients with esophageal hiatus hernia the effect of metoclopramide bromide and metoclopramide chloride compared with placebo, was studied by the double blind method. Both drugs produced an increase of the lower esophageal sphincter pressure and of the peristalsis of the lower third of the esophagus, only being statistically significative the action of metoclopramide chloride on the perstalsis. No significative side-effects were noted.
采用双盲法对10例食管裂孔疝患者进行研究,比较了溴化胃复安和氯化胃复安与安慰剂的效果。两种药物均使食管下括约肌压力及食管下三分之一段的蠕动增强,仅氯化胃复安对蠕动的作用具有统计学意义。未观察到明显的副作用。