Meistrup-Larsen K I, Hermann S, Permin H
Acta Neurol Scand. 1979 Jul;60(1):50-5. doi: 10.1111/j.1600-0404.1979.tb02950.x.
An account is given of chronic diphenyl hydantion (DPH) encephalopathy in 21 mentally retarded epileptics with increasing psychomotor deterioration, choreiform hyperkinesia, deposits of immunoglobulins in the skin, and changes in serum immunoglobulins. Three months after withdrawal of DPH the condition proved partially reversible, from the clinical as well as laboratory point of view. Eleven patients have been followed for 1 year after discontinuation of DPH, and the findings were largely unchanged from the 3-month follow-up examination. Before the drug was withdrawn, seven patients exhibited deposits of immunoglobulins at the dermo-epidermal junction and in vessel walls. At the end of 1 year such deposits were found in only three patients, all of whom were on another antiepileptic drug.
本文报道了21例智力发育迟缓的癫痫患者的慢性苯妥英（DPH）脑病，这些患者出现精神运动功能逐渐恶化、舞蹈样运动增多、皮肤免疫球蛋白沉积以及血清免疫球蛋白变化。停用DPH三个月后，从临床和实验室角度来看，病情证明部分可逆。11例患者在停用DPH后随访了1年，结果与3个月的随访检查相比基本没有变化。在停药前，7例患者在真皮表皮交界处和血管壁出现免疫球蛋白沉积。1年后，仅在3例患者中发现此类沉积，所有这些患者都在服用另一种抗癫痫药物。
