Guazzi M, Fiorentini C, Olivari M T, Polese A
Am J Cardiol. 1979 Oct 22;44(5):1007-12. doi: 10.1016/0002-9149(79)90236-4.
On the basis of echocardiographic measurements, 46 patients with established, uncomplicated primary hypertension (diastolic pressure = 100 mm Hg) were classified as: those with a normal-sized heart (Group I, 13 patients); those with left ventricular concentric hypertrophy (Group II, 19 patients); and those with left ventricular hypertrophy and enlargement (Group III, 14 patients). Eighteen age-matched healthy subjects were investigated as the controls. The function of both the left and right ventricle, evaluated by the stroke index-filling pressure relation and by the mean rate of ejection, was maintained in Group I, augmented in Group II and reduced in Group III, in comparison with the controls. Left ventricular mean rate of circumferential fiber shortening (Vcf) was normal in Group I, significantly augmented in Group II and definitely reduced in Group III. It could not be established whether the divergent variation from normal of the Vcf in Groups II and III reflected opposite changes in ventricular contractility or in afterload (wall stress during ejection), or both. However, the parallel functional pattern of the right and left ventricle in these two groups suggests a functional interdependence of the two sides which cannot be interpreted in terms of afterload but is best explained by changes in the contractile state of the whole heart.
根据超声心动图测量结果，46例确诊为单纯原发性高血压（舒张压 = 100 mmHg）的患者被分为：心脏大小正常组（I组，13例患者）；左心室向心性肥厚组（II组，19例患者）；以及左心室肥厚并扩大组（III组，14例患者）。18名年龄匹配的健康受试者作为对照进行研究。与对照组相比，通过每搏指数-充盈压关系和平均射血速率评估的左、右心室功能，在I组中保持正常，在II组中增强，在III组中降低。I组左心室平均圆周纤维缩短速率（Vcf）正常，II组显著增强，III组明显降低。无法确定II组和III组Vcf与正常情况的差异变化是反映心室收缩性还是后负荷（射血期壁应力）的相反变化，或者两者皆有。然而，这两组中左、右心室平行的功能模式表明两侧存在功能相互依存关系，这不能用后负荷来解释，而最好用全心收缩状态的变化来解释。
