氯喹：作用方式
Chloroquine: mode of action.
作者信息
Ciak J, Hahn F E
出版信息
Science. 1966 Jan 21;151(3708):347-9. doi: 10.1126/science.151.3708.347.
PMID:4955293
Abstract
The drug chloroquine is bactericidal for Bacillus megaterium; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine.
摘要
药物氯喹对巨大芽孢杆菌具有杀菌作用；它抑制DNA和RNA的生物合成，并使核糖体迅速降解以及核糖体RNA异化。也观察到蛋白质合成受到抑制，这显然是一种次要效应。有人提出抑制DNA复制是氯喹抗菌作用的一般机制。
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