伯氨喹的抗菌作用：体外对多肽合成及体内对核糖体和核糖体核糖核酸的影响
Antibacterial action of primaquine: effects in vitro on polypeptide synthesis and in vivo on ribosomes and ribosomal ribonucleic acid.
作者信息
Olenick J G
出版信息
Antimicrob Agents Chemother. 1975 Dec;8(6):754-6. doi: 10.1128/AAC.8.6.754.
Abstract
Primaquine inhibited polyphenylalanine formation directed by poly(U) in a cell-free system obtained from Bacillus megaterium only when the drug was preincubated with transfer ribonucleic acid (tRNA), poly(U), or ribosomes. Considerably less inhibition was produced when the ionic strength of the preincubation mixture of tRNA or poly(U) plus primaquine was increased; with ribosomes, the extent of inhibition was only slightly reduced. In cultures of B. megaterium, primaquine induced the breakdown of ribosomes and their RNA.
摘要
仅当药物与转移核糖核酸（tRNA）、聚尿苷酸（poly(U)）或核糖体预孵育时，伯氨喹才能在从巨大芽孢杆菌获得的无细胞体系中抑制由聚尿苷酸（poly(U)）指导的聚苯丙氨酸的形成。当tRNA或聚尿苷酸（poly(U)）与伯氨喹的预孵育混合物的离子强度增加时，产生的抑制作用明显减少；对于核糖体，抑制程度仅略有降低。在巨大芽孢杆菌培养物中，伯氨喹诱导核糖体及其RNA的分解。
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本文引用的文献
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Antimalarials: effects on in vivo and in vitro protein synthesis.
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Chloroquine and primaquine inhibition of rat liver cell-free polynucleotide-dependent polypeptide synthesis.氯喹和伯氨喹对大鼠肝细胞无细胞多核苷酸依赖性多肽合成的抑制作用。
Biochem Pharmacol. 1972 Feb 1;21(3):391-9. doi: 10.1016/0006-2952(72)90350-4.
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Conformational changes in Escherichia coli ribosomes at low magnesium ion concentrations.低镁离子浓度下大肠杆菌核糖体的构象变化
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